December 4, 2023

Scientists at Penn State have developed a microneedle bandage that may quickly cease bleeding. Uncontrolled bleeding following a traumatic damage is a serious reason behind dying within the younger, and creating new medical applied sciences that may quickly cease bleeding can be extremely helpful. This bandage comprises an array of biodegradable and biocompatible microneedles made utilizing a gelatin methacryloyl biomaterial. The machine additionally comprises silicate nanoplatelets that give it its hemostatic properties, and the needle construction will increase the floor space for blood contact and helps to bind the bandage to the injured tissue.

Blood loss is a number one reason behind dying for People underneath the age of 46. If a traumatic damage happens, then stopping blood loss is the primary precedence. Blood loss from some accidents may be stopped by making use of a tourniquet, however this isn’t doable in each scenario and for each damage. A ready-to-use, extremely efficient hemostatic bandage can be a very helpful element in first support kits or navy subject kits as a first-line protection in opposition to these conditions.   

“Extreme bleeding is a critical problem for human well being,” mentioned Amir Sheikhi, a researcher concerned within the examine. “With hemorrhaging accidents, it’s typically the lack of blood — not the damage itself — that causes dying. There’s an unmet medical want for ready-to-use biomaterials that promote fast blood coagulation.” 

These researchers turned to microneedle arrays as a method to cease bleeding. Medgadget has reported on microneedle bandages earlier than, however sometimes they’re conceived as a method of drug or vaccine supply. On this paradigm, the microneedles act to considerably enhance the floor space of the bandage that contacts the blood rising from the wound, and enhance the adhesion between the bandage and the wound, which additionally helps with wound closure.

To this point, the researchers have examined the bandage in a rat liver bleeding mannequin, the place it confirmed spectacular efficacy and lowered bleeding by roughly 92% in contrast with an untreated management group. The bandages additionally outperformed a business hemostat in decreasing bleeding.

In vitro, the engineered microneedle arrays lowered clotting time from 11.5 minutes to 1.3 minutes; and in a rat liver bleeding mannequin, they lowered bleeding by greater than 90%,” mentioned Sheikhi. “These 10 minutes might be the distinction between life and dying.”

Examine in journal Bioactive Supplies: Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment

Through: Penn State